Abstract
In this retrospective cohort study, the response to routinely administered Haemophilus influenzae type B vaccine, pneumococcal and pertussis vaccinations in 27 children exposed to antitumor necrosis factor alpha (anti-TNFα) during pregnancy was measured. The overall vaccination response seems comparable for children exposed to anti-TNFα and healthy infants. After primary vaccination series, inadequate response was present in some patients and might be related to exposure to anti-TNFα.
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Bacterial / blood*
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Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
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Diphtheria-Tetanus-Pertussis Vaccine / immunology*
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Female
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Haemophilus Vaccines / administration & dosage
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Haemophilus Vaccines / immunology*
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Humans
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Immune System / drug effects*
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Immune System / immunology
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Immunoglobulin G / blood
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Infant
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Infant, Newborn
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Lymphocyte Subsets / drug effects
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Pregnancy
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Retrospective Studies
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Tumor Necrosis Factor-alpha / administration & dosage
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Tumor Necrosis Factor-alpha / antagonists & inhibitors*
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Tumor Necrosis Factor-alpha / blood
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Tumor Necrosis Factor-alpha / immunology*
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Vaccination
Substances
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Antibodies, Bacterial
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Diphtheria-Tetanus-Pertussis Vaccine
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Haemophilus Vaccines
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Immunoglobulin G
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Tumor Necrosis Factor-alpha