Response to Vaccination in Infants Exposed to Antitumor Necrosis Factor Alpha In Utero

Pediatr Infect Dis J. 2021 Oct 1;40(10):912-916. doi: 10.1097/INF.0000000000003271.

Abstract

In this retrospective cohort study, the response to routinely administered Haemophilus influenzae type B vaccine, pneumococcal and pertussis vaccinations in 27 children exposed to antitumor necrosis factor alpha (anti-TNFα) during pregnancy was measured. The overall vaccination response seems comparable for children exposed to anti-TNFα and healthy infants. After primary vaccination series, inadequate response was present in some patients and might be related to exposure to anti-TNFα.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Bacterial / blood*
  • Diphtheria-Tetanus-Pertussis Vaccine / administration & dosage
  • Diphtheria-Tetanus-Pertussis Vaccine / immunology*
  • Female
  • Haemophilus Vaccines / administration & dosage
  • Haemophilus Vaccines / immunology*
  • Humans
  • Immune System / drug effects*
  • Immune System / immunology
  • Immunoglobulin G / blood
  • Infant
  • Infant, Newborn
  • Lymphocyte Subsets / drug effects
  • Pregnancy
  • Retrospective Studies
  • Tumor Necrosis Factor-alpha / administration & dosage
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / blood
  • Tumor Necrosis Factor-alpha / immunology*
  • Vaccination

Substances

  • Antibodies, Bacterial
  • Diphtheria-Tetanus-Pertussis Vaccine
  • Haemophilus Vaccines
  • Immunoglobulin G
  • Tumor Necrosis Factor-alpha