Increased Retinal Vessel Tortuosity Associated With Crimean-Congo Hemorrhagic Fever in Children

Pediatr Infect Dis J. 2021 Oct 1;40(10):880-884. doi: 10.1097/INF.0000000000003187.


Background: To evaluate the ocular symptoms and findings of children diagnosed with Crimean-Congo hemorrhagic fever (CCHF).

Methods: In this prospective study, children diagnosed with CCHF who underwent a complete ophthalmologic examination during the hospitalization period were included.

Results: Twenty-four children with a mean age of 12.4 ± 3.6 years were included study. The most common ocular finding was conjunctival hyperemia and was observed in 50% of patients. Nine (37.4%) children had abnormalities in fundus examination. Two (8.3%) of them had dilated retinal veins, and 7 (29.1%) had tortuous retinal vessels. No significant difference was found between mild to moderate and severe disease groups in terms of ocular symptoms and ophthalmologic examination findings (P > 0.05, for all).

Conclusions: The increased retinal vessel tortuosity was detected as a fundus examination finding in children with CCHF. Both ophthalmologists and pediatricians should be aware of the various ocular manifestations of CCHF for rapid diagnosis and management.

MeSH terms

  • Adolescent
  • Child
  • Conjunctiva / pathology
  • Conjunctiva / virology
  • Female
  • Hemorrhagic Fever Virus, Crimean-Congo / pathogenicity*
  • Hemorrhagic Fever, Crimean / complications*
  • Hemorrhagic Fever, Crimean / physiopathology*
  • Hemorrhagic Fever, Crimean / virology
  • Hospitalization / statistics & numerical data
  • Humans
  • Male
  • Prospective Studies
  • Retinal Vessels / pathology*
  • Retinal Vessels / virology*