Inflammasome Activation in Children With Kawasaki Disease and Multisystem Inflammatory Syndrome

Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):2509-2511. doi: 10.1161/ATVBAHA.121.316210. Epub 2021 Jul 15.

Abstract

[Figure: see text].

Keywords: Kawasaki disease; MIS-C; TIFA; caspase; inflammasome.

Publication types

  • Comparative Study
  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / blood
  • Adaptor Proteins, Signal Transducing / genetics
  • COVID-19 / blood
  • COVID-19 / genetics
  • COVID-19 / immunology*
  • Caspase 1 / blood
  • Caspase 1 / genetics
  • Caspases, Initiator / blood
  • Caspases, Initiator / genetics
  • Gene Expression Profiling
  • Granulocytes / immunology*
  • Granulocytes / metabolism
  • Humans
  • Inflammasomes / genetics
  • Inflammasomes / immunology*
  • Inflammasomes / metabolism
  • Inflammation Mediators / blood
  • Inflammation Mediators / immunology*
  • Interleukin-1beta / blood
  • Interleukin-1beta / genetics
  • Mucocutaneous Lymph Node Syndrome / blood
  • Mucocutaneous Lymph Node Syndrome / genetics
  • Mucocutaneous Lymph Node Syndrome / immunology*
  • NLR Family, Pyrin Domain-Containing 3 Protein / genetics
  • NLR Family, Pyrin Domain-Containing 3 Protein / immunology*
  • NLR Family, Pyrin Domain-Containing 3 Protein / metabolism
  • Neutrophils / immunology*
  • Neutrophils / metabolism
  • Systemic Inflammatory Response Syndrome / blood
  • Systemic Inflammatory Response Syndrome / genetics
  • Systemic Inflammatory Response Syndrome / immunology*
  • Transcriptome

Substances

  • Adaptor Proteins, Signal Transducing
  • IL1B protein, human
  • Inflammasomes
  • Inflammation Mediators
  • Interleukin-1beta
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • NLRP3 protein, human
  • TIFA protein, human
  • CASP4 protein, human
  • Caspases, Initiator
  • Caspase 1

Supplementary concepts

  • pediatric multisystem inflammatory disease, COVID-19 related