Klüver-Bucy syndrome secondary to a nondominant middle cerebral artery ischemic stroke: a case report and review of the literature

J Med Case Rep. 2021 Jul 15;15(1):346. doi: 10.1186/s13256-021-02932-0.


Background: Klüver-Bucy syndrome is a rare and complex neurobehavioral cluster that occurs in humans and results from a temporal lobe lesion. It can be associated with a variety of causes. Stroke is a rarely reported cause of this syndrome.

Case presentation: In this report, we present the case of a 68-year-old Saudi male who developed Klüver-Bucy syndrome subsequent to a nondominant middle cerebral artery ischemic stroke involving right temporal lobe. The patient manifested most of the Klüver-Bucy syndrome clinical features, including hypersexuality, hyperphagia, hyperorality, and visual hypermetamorphosis (excessive tendency to react to every visual stimulation with a tendency to touch every such stimulus). These neurobehavioral manifestations improved after he was started on treatment.

Conclusions: The clinical course, anatomical association relying on pathophysiology, and potential treatment have all been deliberated in regard to the rare occurrence of Klüver-Bucy syndrome resulting from temporal lobe pathology.

Keywords: Case report; Ischemic stroke; Klüver–Bucy syndrome; Neurobehavioral symptoms; Stroke; Temporal lobe damage.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Brain Ischemia*
  • Humans
  • Ischemic Stroke*
  • Kluver-Bucy Syndrome* / etiology
  • Male
  • Middle Cerebral Artery
  • Stroke* / diagnostic imaging
  • Stroke* / etiology