LFA-1 in T cell priming, differentiation, and effector functions

Trends Immunol. 2021 Aug;42(8):706-722. doi: 10.1016/j.it.2021.06.004. Epub 2021 Jul 12.


The integrin LFA-1 is crucial for T cell entry into mammalian lymph nodes and tissues, and for promoting interactions with antigen-presenting cells (APCs). However, it is increasingly evident that LFA-1 has additional key roles beyond the mere support of adhesion between T cells, the endothelium, and/or APCs. These include roles in homotypic T cell-T cell (T-T) communication, the induction of intracellular complement activity underlying Th1 effector cell polarization, and the support of long-lasting T cell memory. Here, we briefly summarize current knowledge of LFA-1 biology, discuss novel cytoskeletal regulators of LFA-1 functions, and review new aspects of LFA-1 mechanobiology that are relevant to its function in immunological synapses and in specific pathologies arising from LFA-1 dysregulation.

Keywords: LFA-1; PTPN22; WNK1; adhesion; complement; mechanosensing; mechanotransduction.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigen-Presenting Cells
  • Cell Differentiation
  • Intercellular Adhesion Molecule-1*
  • Lymphocyte Function-Associated Antigen-1*
  • Th1 Cells


  • Lymphocyte Function-Associated Antigen-1
  • Intercellular Adhesion Molecule-1