Kyushu University Hospital has been designated as a Core Hospital for Cancer Genomic Medicine since February 2018. Our institution promotes cancer genomic medicine collaborating with 10 Cooperative Hospitals for Cancer Genomic Medicine among Kyushu region. Over 500 solid tumor cases have been examined by cancer genomic profiling tests and the results have been intensively evaluated and discussed in the expert panel meetings. To expand cancer genomic medicine for Kyushu region, we have started a consultation desk for the cancer patients in the local community and began educating programs as cancer genomic medicine seminars for the medical staff of Cooperative Hospitals for Cancer Genomic Medicine. A consultation system has been established to discuss the indication of"Patient requested medical care system". Kyushu University Hospital is now focusing on rare cancer care and medical genetics. Thus close cooperation with cancer genomic medicine and each department has been started. We would like to look back on current progress and issues of cancer genomic medicine in Kyushu University Hospital.