Ductal Variant of Prostate Cancer: Serial Imaging With 18F-PSMA PET/CT

Clin Nucl Med. 2021 Nov 1;46(11):e551-e552. doi: 10.1097/RLU.0000000000003799.

Abstract

A 51-year-old man with high-grade ductal variant of prostate cancer with normal prostate-specific antigen (PSA) levels underwent radical prostatectomy. Follow-up 18F-prostate-specific membrane antigen-targeted ligand 1007 (PSMA-1007) PET/CT revealed enlarged PSMA-expressing left common iliac node. Patient was placed on androgen deprivation therapy and was lost to follow-up. Repeat 18F-PSMA PET/CT scan after 16 months showed disease progression. PSA levels were still within normal limits. This case highlights the utility of 18F-PSMA PET/CT for staging and follow-up of patients with this rare ductal variant prostate cancer with normal PSA levels.

Publication types

  • Case Reports

MeSH terms

  • Androgen Antagonists
  • Humans
  • Lymph Nodes
  • Male
  • Middle Aged
  • Positron Emission Tomography Computed Tomography*
  • Prostate-Specific Antigen
  • Prostatectomy
  • Prostatic Neoplasms* / diagnostic imaging
  • Prostatic Neoplasms* / surgery

Substances

  • Androgen Antagonists
  • Prostate-Specific Antigen