Decoding the complexity of circular RNAs in cardiovascular disease

Pharmacol Res. 2021 Sep:171:105766. doi: 10.1016/j.phrs.2021.105766. Epub 2021 Jul 13.


Circular RNAs (circRNAs) are a new class of covalently circularized noncoding RNAs widely expressed in the human heart. Emerging evidence suggests they have a regulatory role in a variety of cardiovascular diseases (CVDs). This review's current focus includes our understanding of circRNA classification, biogenesis, function, stability, degradation mechanisms, and their roles in various cardiovascular disease conditions. Our knowledge of circRNA, the relatively recent member of the noncoding RNA family, is still in its infancy; however, recent literature proposes circRNAs may be promising targets for the understanding and treatment of CVD.

Keywords: Cardiovascular Disease; Circular RNA; RNA binding proteins and micro RNA.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular Diseases / genetics*
  • Humans
  • RNA, Circular* / metabolism


  • RNA, Circular