Configurational entropy of native proteins

M Karplus; T Ichiye; B M Pettitt

doi:10.1016/S0006-3495(87)83303-9

Configurational entropy of native proteins

Biophys J. 1987 Dec;52(6):1083-5. doi: 10.1016/S0006-3495(87)83303-9.

Authors

M Karplus¹, T Ichiye, B M Pettitt

Affiliation

¹ Department of Chemistry, Harvard University, Cambridge, Massachusetts 02138.

Abstract

Simulations of the residual configurational entropy of a protein in the native state suggest that it is nearly an order of magnitude larger than the entropy of denaturation. The implications of this result are discussed.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Mathematics
Protein Conformation*
Proteins*
Thermodynamics

Substances

Proteins