Pediatric morphea state-of-the-art literature review: Reframing morphea as a systemic disease

Pediatr Dermatol. 2021 Sep;38(5):1020-1031. doi: 10.1111/pde.14688. Epub 2021 Jul 17.

Abstract

Pediatric morphea is an inflammatory, fibrosing dermatologic disorder. Although morphea may be localized to the skin and subcutaneous tissues, differentiating it from systemic sclerosis, there is increasing evidence that morphea is a manifestation of a systemic inflammatory process, with the potential to involve many organ systems. Given the potential risk for irreversible sequelae, pediatric morphea should be treated early and aggressively. Long-term disease monitoring is essential.

Keywords: localized; morphea; scleroderma; skin signs of systemic disease.

Publication types

  • Review

MeSH terms

  • Child
  • Disease Progression
  • Humans
  • Scleroderma, Localized* / diagnosis
  • Scleroderma, Systemic*
  • Skin