Tissue distribution of γδ T cell subsets in oesophageal adenocarcinoma

Clin Immunol. 2021 Aug;229:108797. doi: 10.1016/j.clim.2021.108797. Epub 2021 Jul 15.


The global obesity epidemic is contributing to increased prevalence of diseases fuelled by chronic inflammation, including cancer. Oesophageal adenocarcinoma (OAC) is an obesity-associated malignancy with increasing prevalence, dismal prognosis, and severely dysregulated immune processes. We previously reported that αβ T cells migrate to omentum and liver in OAC and contribute to inflammation in these tissues. Here, we assessed the tissue distribution and phenotype of gamma/delta (γδ) T cells in the blood, omentum, liver and tumour of OAC patients. Our data show that the Vδ1 and Vδ3 subsets of γδ T cells are most prevalent in omentum and liver of OAC patients. Furthermore, γδ T cells are predominantly pro-inflammatory in these tissues, and co-express IFN-γ and IL-17. Moreover, γδ T cells exhibit cytotoxic capabilities in OAC omentum and liver. This study provides the first indication that γδ T cells contribute to obesity-associated inflammation in OAC and might be exploited therapeutically.

Keywords: Inflammation; Obesity; Oesophageal adenocarcinoma; Omentum; γδ T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / etiology
  • Adenocarcinoma / immunology*
  • Adenocarcinoma / pathology
  • Adult
  • Aged
  • Aged, 80 and over
  • Cell Degranulation
  • Esophageal Neoplasms / etiology
  • Esophageal Neoplasms / immunology*
  • Esophageal Neoplasms / pathology
  • Female
  • Humans
  • Immunophenotyping
  • Inflammation / complications
  • Interferon-gamma / metabolism
  • Interleukin-17 / metabolism
  • Liver / immunology
  • Liver / pathology
  • Lysosomal-Associated Membrane Protein 1 / metabolism
  • Male
  • Middle Aged
  • Obesity / complications
  • Omentum / immunology
  • Omentum / pathology
  • Receptors, Antigen, T-Cell, gamma-delta / metabolism*
  • Receptors, CCR6 / metabolism
  • T-Lymphocyte Subsets / immunology*
  • T-Lymphocyte Subsets / pathology
  • T-Lymphocyte Subsets / physiology
  • Tissue Distribution


  • CCR6 protein, human
  • IFNG protein, human
  • Interleukin-17
  • Lysosomal-Associated Membrane Protein 1
  • Receptors, Antigen, T-Cell, gamma-delta
  • Receptors, CCR6
  • Interferon-gamma

Supplementary concepts

  • Adenocarcinoma Of Esophagus