Catastrophic antiphospholipid syndrome during pregnancy

Eur J Obstet Gynecol Reprod Biol. 2021 Sep:264:21-24. doi: 10.1016/j.ejogrb.2021.07.002. Epub 2021 Jul 7.

Abstract

Catastrophic antiphospholipid syndrome (CAPS) is an uncommon and the most severe form of antiphospholipid syndrome (APS). A 33-week pregnant patient with Klippel-Trenaunay syndrome, past SARS-CoV-2 infection and type I fetal growth restriction with shortening of the fetal long bone was diagnosed in our center with a probable CAPS. Cesarean section was performed four days after the diagnosis due to the torpid evolution of the patient. Clinical improvement was noted a few days later and the mother and baby were discharged within a week. We review the current literature on CAPS during pregnancy and provide an updated view.

Keywords: Antiphospholipid syndrome; Catastrophic antiphospholipid syndrome; Fetal growth restriction; Klippel-Trenaunay syndrome; Pregnancy; SARS-CoV-2.

Publication types

  • Review

MeSH terms

  • Antiphospholipid Syndrome* / complications
  • Antiphospholipid Syndrome* / diagnosis
  • COVID-19*
  • Cesarean Section
  • Female
  • Humans
  • Pregnancy
  • Pregnancy Complications*
  • SARS-CoV-2