Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution

Brain Res. 1987 Nov 3;425(1):182-5. doi: 10.1016/0006-8993(87)90498-7.


Twenty-four male mice, belonging to 8 different inbred strains, were tested in an 8-arm radial maze. Clear strain differences were found for performance on the third day of training, which correlated very strongly with the size of the hippocampal intra- and infrapy ramidal mossy fibre (iip-MF) terminal fields. These results, combined with those from earlier experiments, indicate that genetic variations of the iip-MF projection influence processes that determine behavioural abilities of mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Behavior, Animal / physiology*
  • Hippocampus / anatomy & histology*
  • Male
  • Mice
  • Nerve Fibers / anatomy & histology*
  • Rats
  • Rats, Inbred Strains