Joint hub identification for brain networks by multivariate graph inference

Med Image Anal. 2021 Oct;73:102162. doi: 10.1016/j.media.2021.102162. Epub 2021 Jul 7.

Abstract

Recent developments in neuroimaging allow us to investigate the structural and functional connectivity between brain regions in vivo. Mounting evidence suggests that hub nodes play a central role in brain communication and neural integration. Such high centrality, however, makes hub nodes particularly susceptible to pathological network alterations and the identification of hub nodes from brain networks has attracted much attention in neuroimaging. Current popular hub identification methods often work in a univariate manner, i.e., selecting the hub nodes one after another based on either heuristic of the connectivity profile at each node or predefined settings of network modules. Since the topological information of the entire network (such as network modules) is not fully utilized, current methods have limited power to identify hubs that link multiple modules (connector hubs) and are biased toward identifying hubs having many connections within the same module (provincial hubs). To address this challenge, we propose a novel multivariate hub identification method. Our method identifies connector hubs as those that partition the network into disconnected components when they are removed from the network. Furthermore, we extend our hub identification method to find the population-based hub nodes from a group of network data. We have compared our hub identification method with existing methods on both simulated and human brain network data. Our proposed method achieves more accurate and replicable discovery of hub nodes and exhibits enhanced statistical power in identifying network alterations related to neurological disorders such as Alzheimer's disease and obsessive-compulsive disorder.

Keywords: Brain network; Connector hub; Graph spectrum; Hub identification.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alzheimer Disease* / diagnostic imaging
  • Brain* / diagnostic imaging
  • Humans
  • Magnetic Resonance Imaging
  • Neural Pathways