Antidepressants and the risk of myocardial infarction among patients with diabetes: A population-based cohort study

J Affect Disord. 2021 Nov 1;294:109-114. doi: 10.1016/j.jad.2021.06.078. Epub 2021 Jul 8.


Objective: To investigate the impact of antidepressants (ATDs) on the risk of myocardial infarction (MI) among patients with diabetes mellitus (DM).

Methods: This was a retrospective population-based cohort study that used data obtained from the National Health Insurance Research Database in Taiwan. The study cohort included diabetic patients who were older than 50 years from 1997 to 2010. We then randomly assigned individuals to the matched cohort at a 1:1 ratio according to their demographic data. Both study and matched cohorts were followed up to compare the risk of MI between patients with and without ATD use from 2000 until the end of 2013. Multivariate Cox proportional hazards models were used to evaluate the relationship between ATD treatment and the occurrence of MI.

Results: After adjustment for confounders, patients with ATD use of more than 180 days had a lower risk of MI than those without ATD use in the matched cohort (adjusted hazard ratio [HR] = 0.68, 95% confidence interval [CI], 0.66-0.71). The adjusted HRs of MI were 0.77 (95% CI, 0.73-0.81) and 0.56 (95% CI, 052.-0.60) in patients with DM and ATD use of 180 > cDDD ≥ 28 and cDDD ≥ 180, respectively. When the duration of ATD treatment was 180 days or longer, MI risk was significantly reduced (after adjustment) for all classes of ATD except bupropion.

Conclusions: Most ATDs, but not bupropion, were associated with significantly reduced risk of MI among the DM population.

Keywords: Antidepressants; Diabetes mellitus; Myocardial infarction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antidepressive Agents / adverse effects
  • Cohort Studies
  • Diabetes Mellitus* / epidemiology
  • Humans
  • Myocardial Infarction* / epidemiology
  • Proportional Hazards Models
  • Retrospective Studies
  • Risk Factors
  • Taiwan / epidemiology


  • Antidepressive Agents