Selective HLA restriction enables the evaluation and interpretation of immunogenic breadth at comparable levels to that observed with broader HLA distribution

Proteomics. 2021 Sep;21(17-18):e2100121. doi: 10.1002/pmic.202100121. Epub 2021 Aug 1.


Existing approaches to identifying predictive T-cell epitopes have traditionally utilized either 2-digit HLA super-families or more commonly utilizing autologous HLA alleles to facilitate the predictions. However, the use of these criteria may not consider the HLA representation within any target population. Here we propose a modification to concept of utilizing autologous HLA whereby subsets of individuals are selected for their specific HLA allele profiles and the representation they provide within a given population. Using this selective approach to HLA selection and the linkages to specific individuals may enable the design of more targeted experimentalstrategies.

Keywords: HLA diversity; HLA frequency; immunogenic breath; predicted T-cell epitopes.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Alleles
  • Epitopes, T-Lymphocyte*
  • HLA-A2 Antigen*
  • Histocompatibility Antigens
  • Histocompatibility Antigens Class I
  • Humans


  • Epitopes, T-Lymphocyte
  • HLA-A2 Antigen
  • Histocompatibility Antigens
  • Histocompatibility Antigens Class I