Thymic Adenocarcinoma with Positivity for Thyroid Transcription Factor-1 and a BRAF V600E Mutation

Intern Med. 2022 Feb 1;61(3):385-388. doi: 10.2169/internalmedicine.7623-21. Epub 2021 Jul 17.


Thymic adenocarcinomas are rare. We herein report for the first time a case of thymic adenocarcinoma with positivity for thyroid transcription factor-1 (TTF-1) and a BRAF V600E mutation. A 50-year-old woman had persistent suffocation and chest pain. Computed tomography revealed a 42×28-mm tumor in the anterior mediastinum. The patient underwent tumor resection using video-assisted thoracoscopic surgery. Histopathological findings showed thymic papillary adenocarcinoma, Masaoka stage II. Immunohistochemically, the tumor was positive for TTF-1. A sequencing analysis revealed a BRAF V600E mutation. The patient underwent postoperative radiotherapy and was in good health without recurrence at five months after resection.

Keywords: BRAF V600E; thymic adenocarcinoma; thymic carcinoma; thymus; thyroid transcription factor-1.

Publication types

  • Case Reports

MeSH terms

  • Female
  • Humans
  • Middle Aged
  • Mutation
  • Proto-Oncogene Proteins B-raf / genetics
  • Thymus Neoplasms* / diagnosis
  • Thymus Neoplasms* / genetics
  • Thyroid Cancer, Papillary
  • Thyroid Neoplasms*


  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf