Twenty-Four-Hour Blood Pressure Variability Is Associated With Lower Cognitive Performance in Young Women With a Recent History of Preeclampsia

Virginia R Nuckols; Amy K Stroud; Jared F Hueser; Debra S Brandt; Lyndsey E DuBose; Donna A Santillan; Mark K Santillan; Gary L Pierce

doi:10.1093/ajh/hpab112

Twenty-Four-Hour Blood Pressure Variability Is Associated With Lower Cognitive Performance in Young Women With a Recent History of Preeclampsia

Am J Hypertens. 2021 Dec 1;34(12):1291-1299. doi: 10.1093/ajh/hpab112.

Authors

Virginia R Nuckols¹, Amy K Stroud¹, Jared F Hueser¹, Debra S Brandt², Lyndsey E DuBose¹, Donna A Santillan², Mark K Santillan^{2

3}, Gary L Pierce^{1

3

4

5}

Affiliations

¹ Department of Health and Human Physiology, University of Iowa, Iowa City, Iowa, USA.
² Department of Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa, USA.
³ Abboud Cardiovascular Research Center, University of Iowa, Iowa City, Iowa, USA.
⁴ Department of Internal Medicine, University of Iowa, Iowa City, Iowa, USA.
⁵ Fraternal Order of Eagles Diabetes Research Center, University of Iowa, Iowa City, Iowa, USA.

Abstract

Background: Women with a history of preeclampsia (hxPE) exhibit sustained arterial stiffness and elevated blood pressure postpartum. Aortic stiffness and 24-hour blood pressure variability (BPV) are associated with age-related cognitive decline. Although hxPE is related to altered cognitive function, the association between aortic stiffness and BPV with cognitive performance in young women with hxPE has not been investigated. The objectives of this study were to (i) test whether cognitive performance is lower in young women with hxPE and (ii) determine whether aortic stiffness and BPV are associated with cognitive performance independent of 24-hour average blood pressure.

Methods: Women with hxPE (N = 23) and healthy pregnancy controls (N = 38) were enrolled 1-3 years postpartum. Cognitive performance was assessed in domains of memory, processing speed, and executive function. Twenty-four-hour ambulatory blood pressure monitoring and carotid-femoral pulse wave velocity (cfPWV) were used to measure BPV and aortic stiffness, respectively.

Results: Women with hxPE had slower processing speed (-0.56 ± 0.17 vs. 0.34 ± 0.11 Z-score, P < 0.001) and lower executive function (-0.43 ± 0.14 vs. 0.31 ± 0.10 Z-score, P = 0.004) compared with controls independent of education, whereas memory did not differ. BPV and cfPWV (adjusted for blood pressure) did not differ between women with hxPE and controls. Greater diastolic BPV was associated with lower executive function independent of 24-hour average blood pressure and education in women with hxPE (r = -0.48, P = 0.03) but not controls (r = 0.15, P = 0.38).

Conclusions: Select cognitive functions are reduced postpartum in young women with a recent hxPE and linked with elevated 24-hour diastolic BPV.

Keywords: ambulatory blood pressure monitoring; blood pressure; hypertension; postpartum; pregnancy/preeclampsia; pulse wave velocity.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Blood Pressure / physiology
Blood Pressure Monitoring, Ambulatory
Cognition / physiology
Female
Humans
Pre-Eclampsia* / diagnosis
Pregnancy
Pulse Wave Analysis
Vascular Stiffness* / physiology

Abstract

Publication types

MeSH terms

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