Hypocholesterolemic Effect of Blackcurrant ( Ribes nigrum) Extract in Healthy Female Subjects: A Pilot Study

Molecules. 2021 Jul 4;26(13):4085. doi: 10.3390/molecules26134085.


Blackcurrant extract (BCE) ameliorates dyslipidemia in menopausal model animals and in elderly women at a risk of dyslipidemia. However, it is unknown whether the daily intake of BCE can prevent lipid abnormalities in healthy individuals. Lipids are essential for the body, but they also cause arteriosclerosis. In this noncomparative pilot study, we examined the effects of BCE administered for 29 days on serum lipids in young healthy women. Blood samples were collected before and on days 4 and 29 after BCE intake, and 20 lipoprotein fractions in the serum were separated using a gel-permeation high-performance liquid chromatography method to measure the triacylglycerol and cholesterol levels in lipoproteins. There were no effects on lipids on day 4 of BCE intake, but the total cholesterol level decreased on day 29. Furthermore, the levels of total very-low-density lipoprotein (VLDL) cholesterol, small VLDL cholesterol, and large low-density lipoprotein cholesterol were significantly decreased. These results suggest that the daily intake of BCE has a hypocholesterolemic effect in healthy women, and that it is effective in preventing atherosclerosis.

Keywords: atherosclerosis; cholesterol; lipoprotein; serum lipid.

MeSH terms

  • Adult
  • Anticholesteremic Agents / pharmacology*
  • Dyslipidemias / blood
  • Dyslipidemias / drug therapy*
  • Dyslipidemias / pathology
  • Female
  • Humans
  • Lipids / blood*
  • Lipoproteins / blood*
  • Pilot Projects
  • Plant Extracts / pharmacology*
  • Ribes / chemistry*
  • Young Adult


  • Anticholesteremic Agents
  • Lipids
  • Lipoproteins
  • Plant Extracts