Corneal Factors Associated with the Amount of Visual Field Damage in Eyes with Newly Diagnosed, Untreated, Open-angle Glaucoma

Ophthalmol Ther. 2021 Sep;10(3):669-676. doi: 10.1007/s40123-021-00375-w. Epub 2021 Jul 19.


Introduction: The aim of this study was to evaluate the correlation between several ocular parameters (intraocular pressure [IOP], corneal biomechanical properties) and the visual field (VF) mean deviation (VF MD) in eyes with open-angle glaucoma (OAG).

Methods: We conducted a cross-sectional, observational study in which we measured the IOP with Goldmann applanation tonometry, the central corneal thickness (CCT), and the corneal parameters obtained from the Ocular Response Analyzer® (ORA®) and the Corvis® ST non-contact tonometer, in newly diagnosed and treatment-naïve eyes with OAG, to investigate whether there was any correlation between these ocular parameters and the VF MD.

Results: A total of 51 eyes were analyzed. A statistically significant correlation was found only between the VF MD and corneal hysteresis (CH) (P = 0.003, r2 = 0.16) and CCT (P = 0.03, r2 = 0.08).

Conclusions: These results demonstrate that CH and CCT are associated with the amount of VF damage in treatment-naïve OAG eyes.

Keywords: Corneal parameters; Examination techniques; Open angle glaucoma; Risk factors; Visual field.