Irritable Bowel Syndrome Therapeutic Has Broad-Spectrum Antimicrobial Activity

Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0044321. doi: 10.1128/AAC.00443-21. Epub 2021 Jul 19.

Abstract

Otilonium bromide is a poorly absorbed oral medication used to control irritable bowel syndrome. It is thought to act as a muscle relaxant in the intestine. Here, we show that otilonium bromide has broad-spectrum antibacterial and antifungal activity, including against multidrug-resistant strains. Our results suggest otilonium bromide acts on enteric pathogens and may offer a new scaffold for poorly absorbed intestinal antimicrobial therapy.

Keywords: antibacterial; antifungal; otilonium bromide.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Humans
  • Intestines
  • Irritable Bowel Syndrome* / drug therapy
  • Quaternary Ammonium Compounds

Substances

  • Quaternary Ammonium Compounds