Sterilizing Effects of Novel Regimens Containing TB47, Clofazimine, and Linezolid in a Murine Model of Tuberculosis

Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0070621. doi: 10.1128/AAC.00706-21. Epub 2021 Jul 19.


TB47, a new drug candidate targeting QcrB in the electron transport chain, has shown a unique synergistic activity with clofazimine and forms a highly sterilizing combination. Here, we investigated the sterilizing effects of several all-oral regimens containing TB47 plus clofazimine and linezolid as a block and the roles of fluoroquinolones and pyrazinamide in them. All these regimens cured tuberculosis within 4 to 6 months in a well-established mouse model, and adding pyrazinamide showed a significant difference in bactericidal effects.

Keywords: TB47; cytochrome bc1-aa3 oxidase; drug resistance; murine model; tuberculosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antitubercular Agents / therapeutic use
  • Clofazimine / therapeutic use
  • Disease Models, Animal
  • Linezolid
  • Mice
  • Mice, Inbred BALB C
  • Mycobacterium tuberculosis*
  • Tuberculosis* / drug therapy


  • Antitubercular Agents
  • Clofazimine
  • Linezolid