Monosomy 13 in Mammary Myofibroblastoma

Anticancer Res. 2021 Aug;41(8):3747-3751. doi: 10.21873/anticanres.15166.


Background/aim: Myofibroblastoma of the breast is a rare benign mesenchymal tumor whose morphology is similar to that of spindle-cell lipoma. The few hitherto genetically investigated mammary myofibroblastomas have been shown to have had loss of material from chromosome 13, changes that are also common in spindle-cell lipoma. Our aim was to add to the existing knowledge of genetic aberrations in mammary myofibroblastoma by investigating another such tumor.

Materials and methods: Cytogenetic and array comparative genome hybridization (aCGH) analyses were performed on a surgically removed mammary myofibroblastoma from a 76-year-old man.

Results: Short-term cultured cells from the tumor showed the karyotype 45,XY,-13[3]/44~45,idem,add(19)(q13)[cp2]. aCGH detected loss of one entire chromosome 13 and heterozygous loss from 19q between sub-band 19q13.12 and 19qter.

Conclusion: These findings add to the evidence that loss of 13q material is typical of mammary myofibroblastomas.

Keywords: Mammary myofibroblastoma; chromosome 13; cytogenetics; deletion.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Chromosome Banding
  • Chromosomes, Human, Pair 13*
  • Comparative Genomic Hybridization
  • Humans
  • Karyotyping
  • Male
  • Monosomy / genetics*
  • Neoplasms, Muscle Tissue / genetics*