Isolation of placental cadherin cDNA: identification of a novel gene family of cell-cell adhesion molecules

EMBO J. 1987 Dec 1;6(12):3655-61.

Abstract

Ca2+-dependent cell--cell adhesion molecules, termed cadherins, are classified into subclasses with different tissue distributions and distinct cell--cell binding specificities. We report the cloning of cDNA encoding a cadherin present in the placenta which is called P-cadherin. The deduced sequence encodes a polypeptide of 822 amino acids with the characteristic features of integral membrane proteins. A computer search of the amino acid sequence homology of P-cadherin against itself showed that this molecule contains internal repeats in the extracellular domain. Comparison of the primary structure of P-cadherin with that of the epithelial cadherin (E-cadherin) showed that there is 58% homology in their amino acid sequences. These results provide evidence for our hypothesis that cadherins constitute a gene family.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antigens, Surface* / genetics*
  • Base Sequence
  • Calcium-Binding Proteins / genetics*
  • Cell Adhesion Molecules
  • Cell Adhesion*
  • Cloning, Molecular*
  • DNA / isolation & purification*
  • Female
  • Genes*
  • Mice
  • Mice, Inbred ICR
  • Molecular Sequence Data
  • Nucleic Acid Hybridization
  • Placenta / metabolism*
  • Pregnancy

Substances

  • Antigens, Surface
  • Calcium-Binding Proteins
  • Cell Adhesion Molecules
  • DNA

Associated data

  • GENBANK/X06340