Role of proton therapy in reirradiation and in the treatment of sarcomas

Cancer Radiother. 2021 Oct;25(6-7):550-553. doi: 10.1016/j.canrad.2021.06.024. Epub 2021 Jul 17.


Reirradiation and irradiation of sarcoma is often difficult due to the frequent need for a high dose of radiation in order to increase tumor control. This can result in a greater risk of toxicity which can be mitigated with the use of proton therapy. The present review aims to summarize the role of proton therapy in these 2 clinical contexts.

Keywords: Proton Therapy; Protonthérapie; Reirradiation; Réirradiation; Sarcoma; Sarcome.

Publication types

  • Review

MeSH terms

  • Humans
  • Neoplasm Recurrence, Local / radiotherapy*
  • Neoplasms, Second Primary / radiotherapy*
  • Proton Therapy* / adverse effects
  • Radiation Tolerance
  • Re-Irradiation / adverse effects
  • Re-Irradiation / methods*
  • Sarcoma / radiotherapy*