Role of proton therapy in reirradiation and in the treatment of sarcomas

J Doyen; D Aloi; A Groulier; M Vidal; P Lesueur; V Calugaru; P Y Bondiau

doi:10.1016/j.canrad.2021.06.024

Role of proton therapy in reirradiation and in the treatment of sarcomas

Cancer Radiother. 2021 Oct;25(6-7):550-553. doi: 10.1016/j.canrad.2021.06.024. Epub 2021 Jul 17.

Authors

J Doyen¹, D Aloi², A Groulier², M Vidal², P Lesueur³, V Calugaru⁴, P Y Bondiau²

Affiliations

¹ Department of radiation oncology, Centre Antoine-Lacassagne, University of Côte d'Azur, 33, avenue de Valombrose, 06189 Nice, France. Electronic address: jerome.doyen@nice.unicancer.fr.
² Department of radiation oncology, Centre Antoine-Lacassagne, University of Côte d'Azur, 33, avenue de Valombrose, 06189 Nice, France.
³ Department of radiation oncology, Centre François Baclesse, Centre de Protonthérapie de Normandie, University of Caen Normandie, Caen, France.
⁴ Department of radiation oncology, Institut Curie, Centre de Protonthérapie d'Orsay, Orsay, France.

PMID: 34284969
DOI: 10.1016/j.canrad.2021.06.024

Abstract

Reirradiation and irradiation of sarcoma is often difficult due to the frequent need for a high dose of radiation in order to increase tumor control. This can result in a greater risk of toxicity which can be mitigated with the use of proton therapy. The present review aims to summarize the role of proton therapy in these 2 clinical contexts.

Keywords: Proton Therapy; Protonthérapie; Reirradiation; Réirradiation; Sarcoma; Sarcome.

Publication types

Review

MeSH terms

Humans
Neoplasm Recurrence, Local / radiotherapy*
Neoplasms, Second Primary / radiotherapy*
Proton Therapy* / adverse effects
Radiation Tolerance
Re-Irradiation / adverse effects
Re-Irradiation / methods*
Sarcoma / radiotherapy*