CCL27 Signaling in the Tumor Microenvironment

Miguel Martínez-Rodríguez; Carlos Monteagudo

doi:10.1007/978-3-030-62658-7_9

CCL27 Signaling in the Tumor Microenvironment

Adv Exp Med Biol. 2021:1302:113-132. doi: 10.1007/978-3-030-62658-7_9.

Authors

Miguel Martínez-Rodríguez¹, Carlos Monteagudo²

Affiliations

¹ Department of Pathology, Telemark Hospital, Skien, Norway.
² Department of Pathology, University Clinic Hospital-INCLIVA, University of Valencia, Valencia, Spain. carlos.monteagudo@uv.es.

PMID: 34286445
DOI: 10.1007/978-3-030-62658-7_9

Abstract

Chemokines are a group of small proteins which play an important role in leukocyte migration and invasion. They are also involved in the cellular proliferation and migration of tumor cells.Chemokine CCL27 (cutaneous T cell-attracting chemokine, CTACK) is mainly expressed by keratinocytes of the normal epidermis. It is well known that this chemokine plays an important role in several inflammatory diseases of the skin, such as atopic dermatitis, contact dermatitis, and psoriasis. Moreover, several studies have shown an association between CCL27 expression and a variety of neoplasms including skin cancer.In this chapter, we address the role of chemokine CCL27 in the tumor microenvironment in the most relevant cancers of the skin and other anatomical locations. We also make a brief comment on future perspectives and the potential relation of CCL27 with different immunotherapeutic modalities.

Keywords: Angiogenesis; Breast cancer; CCL27; CCR10; Chemokine receptors; Chemokines; Colorectal cancer; Glioblastoma; Immunotherapy; Melanoma, mycosis fungoides; Metastasis; Pericytes; Skin cancer; Tumor microenvironment.

Publication types

Review

MeSH terms

Chemokine CCL27* / genetics
Chemokines, CC
Keratinocytes
Skin
Tumor Microenvironment*

Substances

Chemokine CCL27
Chemokines, CC