Dengue and the heart

Cardiovasc J Afr. 2021;32(5):276-283. doi: 10.5830/CVJA-2021-033. Epub 2021 Jul 20.


Dengue is a neglected viral arthropod-borne tropical disease transmitted by the bite of infected Aedes spp. mosquitoes. It is responsible for a significant global burden of disease and corresponding socio-economic implications. There are four different virus serotypes, all of which are found predominantly in countries with tropical climates. Patients with dengue may present with cardiovascular (CV) manifestations, contributing to associated death and disability. A systematic review was conducted to identify CV manifestations of dengue, wherein 30 relevant studies were identified in the MEDLINE and PubMed databases. CV complications of dengue include rhythm abnormalities, hypotension, myocarditis, pericarditis and deterioration in myocardial function. Prompt recognition and treatment of CV complications of dengue are essential to reduce morbidity and mortality in these patients, who are at risk of progressing to cardiogenic shock and heart failure.

Keywords: cardiovascular involvement; dengue; myocarditis; neglected tropical diseases.

Publication types

  • Review
  • Systematic Review

MeSH terms

  • Animals
  • Dengue / complications*
  • Heart
  • Humans
  • Myocarditis* / complications
  • Myocarditis* / therapy
  • Neglected Diseases*