25 B-cell depleted patients (24 following anti-CD19/20 therapy) diagnosed with COVID-19, had been symptomatic for a median of 26 days but remained antibody negative. All were treated with convalescent plasma with high neutralizing antibody titers. 21 (84%) recovered, indicating the potential therapeutic effects of this therapy in this particular population.
Keywords: B-cell depletion; COVID-19; SARS-CoV-2; convalescent plasma; immunodefiency.
© The Author(s) 2021. Published by Oxford University Press for the Infectious Diseases Society of America.