SARS-CoV-2 Initiates Programmed Cell Death in Platelets

Circ Res. 2021 Sep 3;129(6):631-646. doi: 10.1161/CIRCRESAHA.121.319117. Epub 2021 Jul 23.

Abstract

[Figure: see text].

Keywords: COVID-19; SARS-CoV-2; apoptosis; blood platelets; extracellular vesicles; necroptosis; thrombosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • A549 Cells
  • Adult
  • Angiotensin-Converting Enzyme 2 / metabolism*
  • Apoptosis*
  • Blood Platelets / metabolism*
  • Blood Platelets / ultrastructure
  • Blood Platelets / virology
  • Blotting, Western
  • COVID-19 / blood
  • COVID-19 / metabolism*
  • COVID-19 / virology
  • Female
  • Host-Pathogen Interactions
  • Humans
  • Male
  • Microscopy, Electron, Transmission
  • Necroptosis
  • SARS-CoV-2 / physiology
  • Serine Endopeptidases / metabolism*

Substances

  • ACE2 protein, human
  • Angiotensin-Converting Enzyme 2
  • Serine Endopeptidases
  • TMPRSS2 protein, human