SARS-CoV-2 Initiates Programmed Cell Death in Platelets

Circ Res. 2021 Sep 3;129(6):631-646. doi: 10.1161/CIRCRESAHA.121.319117. Epub 2021 Jul 23.

Milka Koupenova¹, Heather A Corkrey¹, Olga Vitseva¹, Kahraman Tanriverdi¹, Mohan Somasundaran², Ping Liu³, Shaukat Soofi³, Rohan Bhandari^{4

5}, Matthew Godwin⁵, Krishna Mohan Parsi^{6

7}, Alyssa Cousineau⁶, René Maehr^{6

7}, Jennifer P Wang³, Scott J Cameron^{4

5

8}, Jeffrey Rade¹, Robert W Finberg³, Jane E Freedman¹

¹ Department of Medicine, Division of Cardiovascular Medicine (M.K., H.A.C., O.V., K.T., J.R., J.E.F.), University of Massachusetts Medical School, Worcester, MA.
² Department of Biochemistry and Molecular Pharmacology (M.S.), University of Massachusetts Medical School, Worcester, MA.
³ Department of Medicine, Division of Infectious Disease and Immunology Department of Medicine (P.L., S.S., J.P.W., R.W.F.), University of Massachusetts Medical School, Worcester, MA.
⁴ Heart, Vascular and Thoracic Institute (R.B., S.J.C.).
⁵ Department of Cardiovascular and Metabolic Sciences, Cleveland Clinic, OH (R.B., M.G., S.J.C.).
⁶ Diabetes Center of Excellence (K.M.P., A.C., R.M.), University of Massachusetts Medical School, Worcester, MA.
⁷ Program in Molecular Medicine (K.M.P., R.M.), University of Massachusetts Medical School, Worcester, MA.
⁸ Case Western Reserve University Lerner College of Medicine, Cleveland, OH (S.J.C.).

Abstract

[Figure: see text].

Keywords: COVID-19; SARS-CoV-2; apoptosis; blood platelets; extracellular vesicles; necroptosis; thrombosis.