We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunocompromised patients can harbor emerging variants of severe acute respiratory syndrome coronavirus 2.
Keywords: 2019 novel coronavirus disease; COVID-19; California; HIV/AIDS; SARS-CoV-2; United States; antimicrobial resistance; coronavirus disease; coronaviruses; immunocompromised; respiratory infections; severe acute respiratory syndrome coronavirus 2; viral evolution; viruses; zoonoses.