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. 2021 Jul 23;326(11):1063-1065.
doi: 10.1001/jama.2021.12339. Online ahead of print.

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses

Ilies Benotmane  1 , Gabriela Gautier  1 , Peggy Perrin  1 , Jérôme Olagne  1 , Noëlle Cognard  1 , Samira Fafi-Kremer  2 , Sophie Caillard  1
Affiliations

Antibody Response After a Third Dose of the mRNA-1273 SARS-CoV-2 Vaccine in Kidney Transplant Recipients With Minimal Serologic Response to 2 Doses

Ilies Benotmane et al. JAMA. .

Abstract

This study examines the antibody responses to a third dose (100 μg) of the mRNA-1273 SARS-CoV-2 vaccine among kidney transplant recipients in France who had not responded to 2 doses of the vaccine.

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Conflict of interest statement

Conflict of Interest Disclosures: Dr Caillard reported receiving travel grants from Astellas, Novartis, and Sanofi and receiving lecture honoraria from Bristol Myers Squibb. Dr Benotmane reported receiving travel grants from Novartis, Sandoz, Fresenius Medical Care, and Chiesi. No other disclosures were reported.

Figures

Figure.
Figure.. Anti–Receptor-Binding Domain (RBG) IgG Antibody Titers Measured 28 Days After the Third Dose of mRNA-1273 SARS-CoV-2 Vaccine in 159 Kidney Transplant Recipients
Horizontal dotted line indicates the cutoff for positivity (50 arbitrary units [AU]/mL). Blue lines indicate the antibody titers of kidney transplant recipients who seroconverted after the third dose (titers ≥50 AU/mL); orange lines, the evolution of antibody titers among nonresponders (titers <50 AU/mL). mRNA indicates messenger RNA.
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