Vitamin B for treating diabetic peripheral neuropathy - A systematic review

Hanan Khalil; Cynthia D Ang; Viviane Khalil

doi:10.1016/j.dsx.2021.102213

Vitamin B for treating diabetic peripheral neuropathy - A systematic review

Diabetes Metab Syndr. 2021 Sep-Oct;15(5):102213. doi: 10.1016/j.dsx.2021.102213. Epub 2021 Jul 18.

Authors

Hanan Khalil¹, Cynthia D Ang², Viviane Khalil³

Affiliations

¹ School of Psychology and Public Health La Trobe University, 360 Collins Street Melbourne Victoria, Vic, 3000, Australia. Electronic address: h.khalil@latrobe.edu.au.
² Department of Rehabilitation Medicine, University of the Philippines, College of Medicine and Philippine General Hospital, Manila, Philippines.
³ Pharmacy Department, Monash Health, Monash University, Clayton, Vic, Australia.

PMID: 34298270
DOI: 10.1016/j.dsx.2021.102213

Abstract

This systematic review assesses the effectiveness and safety of vitamin B supplements for the management of neuropathy in people with diabetes.

Methods: Several databases including, the Cochrane Neuromuscular Specialised Register, CENTRAL, MEDLINE, Embase and CINAHL Plus were searched from their inception until May 2020.

Results: Five studies were eligible to be included in this review with a total of 348 participants. Overall, the evidence is too uncertain to draw conclusions on the effects of B vitamins in people with DPN.

Conclusion: It is uncertain whether vitamin B supplements change pain intensity or impairment in the short or long term in people with DPN.

Keywords: Diabetes; Impairment; Pain; Peripheral neuropathy; Vitamin B.

Publication types

Systematic Review

MeSH terms

Diabetes Mellitus, Type 2 / complications*
Diabetic Neuropathies / diet therapy*
Diabetic Neuropathies / etiology
Diabetic Neuropathies / pathology
Dietary Supplements*
Humans
Prognosis
Vitamin B Complex / administration & dosage*

Substances

Vitamin B Complex