Functional Properties of Polyurethane Ureteral Stents with PLGA and Papaverine Hydrochloride Coating

Int J Mol Sci. 2021 Jul 19;22(14):7705. doi: 10.3390/ijms22147705.


Despite the obvious benefits of using ureteral stents to drain the ureters, there is also a risk of complications from 80-90%. The presence of a foreign body in the human body causes disturbances in its proper functioning. It can lead to biofilm formation on the stent surface, which may favor the development of urinary tract infections or the formation of encrustation, as well as stent fragmentation, complicating its subsequent removal. In this work, the effect of the polymeric coating containing the active substance-papaverine hydrochloride on the functional properties of ureteral stents significant for clinical practice were assessed. Methods: The most commonly clinically used polyurethane ureteral Double-J stent was selected for the study. Using the dip-coating method, the surface of the stent was coated with a poly(D,L-lactide-glycolide) (PLGA) coating containing the papaverine hydrochloride (PAP). In particular, strength properties, retention strength of the stent ends, dynamic frictional force, and the fluoroscopic visibility of the stent during X-ray imaging were determined. Results: The analysis of the test results indicates the usefulness of a biodegradable polymer coating containing the active substance for the modification of the surface of polyurethane ureteral stents. The stents coated with PLGA+PAP coating compared to polyurethane stents are characterized by more favorable strength properties, the smaller value of the dynamic frictional force, without reducing the fluoroscopic visibility.

Keywords: PLGA with papaverine hydrochloride coatings; break strength; dynamic frictional force; radiopacity; retention strength; ureteral stent.

MeSH terms

  • Absorbable Implants
  • Biocompatible Materials / pharmacology
  • Drug-Eluting Stents*
  • Humans
  • Papaverine / metabolism
  • Papaverine / pharmacology*
  • Polylactic Acid-Polyglycolic Acid Copolymer / pharmacology*
  • Polyurethanes / chemistry
  • Ureteral Obstruction / metabolism
  • Ureteral Obstruction / surgery
  • Ureteral Obstruction / therapy*


  • Biocompatible Materials
  • Polyurethanes
  • Polylactic Acid-Polyglycolic Acid Copolymer
  • Papaverine