Janus Hydrogel Microbeads for Glucose Sensing with pH Calibration

Sensors (Basel). 2021 Jul 15;21(14):4829. doi: 10.3390/s21144829.


We present fluorescent Janus hydrogel microbeads for continuous glucose sensing with pH calibration. The Janus hydrogel microbeads, that consist of fluorescent glucose and pH sensors, were fabricated with a UV-assisted centrifugal microfluidic device. The microbead can calibrate the pH values of its surroundings and enables accurate measurements of glucose within various pH conditions. As a proof of concept, we succeeded in obtaining the accurate value of glucose concentration in a body-fluid-like sample solution. We believe that our fluorescent microbeads, with pH calibration capability, could be applied to fully implantable sensors for continuous glucose monitoring.

Keywords: Janus particle; glucose monitoring; glucose sensor; hydrogel; pH calibration.

MeSH terms

  • Blood Glucose
  • Blood Glucose Self-Monitoring*
  • Calibration
  • Glucose
  • Hydrogels*
  • Hydrogen-Ion Concentration
  • Microspheres


  • Blood Glucose
  • Hydrogels
  • Glucose