Hepatoprotective activity of polyphenolic compounds from Cynara scolymus against CCl4 toxicity in isolated rat hepatocytes

J Nat Prod. Jul-Aug 1987;50(4):612-7. doi: 10.1021/np50052a004.

Abstract

The hepatoprotective activity against CCl4 toxicity in isolated rat hepatocytes of some polyphenolic compounds, such as cynarin, isochlorogenic acid, chlorogenic acid, luteolin-7-glucoside, and two organic acids, caffeic and quinic, from Cynara scolymus, is tested. Only cynarine and, to a lesser extent, caffeic acid showed cytoprotective action. The possible relationship between the molecular structure and the protective effect found is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alanine Transaminase / blood
  • Animals
  • Aspartate Aminotransferases / blood
  • Carbon Tetrachloride Poisoning / prevention & control*
  • Cell Survival / drug effects
  • Chemical and Drug Induced Liver Injury / prevention & control*
  • Flavonoids*
  • Liver / drug effects
  • Liver / pathology
  • Male
  • Phenols / isolation & purification*
  • Phenols / therapeutic use
  • Plants, Medicinal / analysis*
  • Polymers / isolation & purification*
  • Polymers / therapeutic use
  • Polyphenols
  • Rats
  • Rats, Inbred Strains

Substances

  • Flavonoids
  • Phenols
  • Polymers
  • Polyphenols
  • Aspartate Aminotransferases
  • Alanine Transaminase