Clinical significance of sFRP5, RBP-4 and NT-proBNP in patients with chronic heart failure

Yu An; Qingsong Wang; Hong Wang; Na Zhang; Fengming Zhang

Clinical significance of sFRP5, RBP-4 and NT-proBNP in patients with chronic heart failure

Am J Transl Res. 2021 Jun 15;13(6):6305-6311. eCollection 2021.

Authors

Yu An¹, Qingsong Wang¹, Hong Wang¹, Na Zhang¹, Fengming Zhang²

Affiliations

¹ Department of Cardiology, Affiliated Hospital of Chengde Medical College Chengde, Hebei Province, China.
² Chengde Health Commission Chengde, Hebei Province, China.

PMID: 34306370
PMCID: PMC8290780

Abstract

Objective: This study was designed to investigate the levels and clinical significance of secretory frizzled-related protein 5 (sFRP5), retinol binding protein 4 (RBP-4) and N-terminal (NT)-pro hormone BNP (NT-proBNP) in patients with chronic heart failure (CHF).

Methods: Eighty-nine patients with CHF treated in our hospital were included as the observation group. Seventy-five healthy volunteers who underwent physical examination in our hospital during the same period were selected as the control group. The subjects in the observation group were divided into NYHA class II (n=23), NYHA class III (n=34) and NYHA class IV (n=32) according to NYHA classification, and the levels of sFRP5, RBP-4 and NT-proBNP as well as left ventricular end-diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF) were compared in the three groups. Spearman correlation was used to analyze the relationship between sFRP5, RBP-4, NT-proBNP and LVEDD, LVEF. The ROC curves of sFRP5, RBP-4 and NT-proBNP for the diagnosis of CHF were plotted. Patients in the observation group were divided into a death group (n=30) and a survival group (n=59) according to the 1-year follow-up outcome, and the levels of sFRP5, RBP-4, and NT-proBNP were compared between the two groups.

Results: The observation group showed significantly higher levels of sFRP5, RBP-4, NT-proBNP and LVEDD, and a significantly lower level of LVEF than the control group. Spearman's correlation analysis showed that sFRP5, RBP-4, NT-proBNP were correlated with LVEDD and LVEF in CHF patients (P < 0.05). The ROC curve showed that the AUC of sFRP5, RBP-4 and NT-proBNP for CHF diagnosis were 0.9378, 0.9133, and 0.9375, respectively. sFRP5, RBP-4, and NT-proBNP in the death group were all higher than those in the survival group (P < 0.05).

Conclusion: sFRP5, RBP-4, and NT-proBNP showed a close correlation with CHF. It is worthy of using this method as a clinical index for the diagnosis and prognosis of CHF.

Keywords: Chronic heart failure; NT-proBNP; RBP-4; clinical significance; sFRP5.