The relationship between ApoE gene polymorphism and the efficacy of statins controlling hyperlipidemia

Cong Cai; Zhongzheng Wen; Linrui Li

The relationship between ApoE gene polymorphism and the efficacy of statins controlling hyperlipidemia

Am J Transl Res. 2021 Jun 15;13(6):6772-6777. eCollection 2021.

Authors

Cong Cai¹, Zhongzheng Wen², Linrui Li³

Affiliations

¹ Department of Cardiology, Eastern Hospital, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu, Sichuan Province, China.
² Department of Cardiology, Wenjiang District People's Hospital Chengdu, Sichuan Province, China.
³ Department of Cardiology, The Sixth People's Hospital of Chengdu Chengdu, Sichuan Province, China.

PMID: 34306425
PMCID: PMC8290710

Abstract

Objective: To explore the relationship between ApoE gene polymorphism and clinical efficacy of statins on lipidemia.

Methods: Peripheral venous blood was obtained from 220 patients with hyperlipidemia who were admitted to the outpatient department of our hospital. The potential relationship between ApoE gene polymorphism and clinical effect of statins was analyzed.

Results: In the three isomers (E2, E3, E4) of ApoE, expression level of ApoE protein in ApoE4 gene carriers was significantly different from that in E2 or E3 gene carriers (both P<0.05). At the same time, both the decrease rate of total cholesterol (TC) in blood lipid and low density lipoprotein cholesterol (LDL-C) and the rise rate of high density lipoprotein cholesterol (HDL-C) in ApoE4 carriers after taking statins were much lower than those in non-ApoE4 patients (P<0.05).

Conclusion: ApoE gene polymorphism is associated with hyperlipidemia and has certain influence on the clinical efficacy of statins in treatment of hyperlipidemia.

Keywords: ApoE4; clinical efficacy; gene polymorphism; hyperlipidemia; statins.