MTHFR gene polymorphism and homocysteine levels in spontaneous abortion of pregnant women

Linjing Zhang; Hainei Fu; Tao Wei

MTHFR gene polymorphism and homocysteine levels in spontaneous abortion of pregnant women

Am J Transl Res. 2021 Jun 15;13(6):7083-7088. eCollection 2021.

Authors

Linjing Zhang¹, Hainei Fu¹, Tao Wei²

Affiliations

¹ Department of Obstetrics and Gynecology, Hainan Province Women and Children Medical Center Haikou, Hainan Province, China.
² Library, Kunming Medical University Kunming, Yunnan Province, China.

PMID: 34306468
PMCID: PMC8290815

Abstract

Objective: This research explored the expression of MTHFR gene polymorphism and homocysteine (Hcy) in spontaneous abortions in pregnant women.

Methods: Eighty-two spontaneous abortion patients treated in our hospital were selected prospectively, and 82 age-matched healthy and normal delivery women were included. The peripheral venous blood of the two groups was obtained, and the differences between MTHFR gene polymorphism and Hcy levels were analyzed.

Results: The Hcy levels in spontaneous abortion patients were higher than those in the healthy control group (P<0.05). In the common mutation (C677T) of MTHFR gene polymorphism, the distribution of MTHFRC677T (TT, CC, CT) genotyping of both groups was different, but the Hcy levels in the observation group were higher than those in the normal control group (P<0.05). In addition, logistic analysis manifested that the the Hcy levels were higher than normal and MTHFRC677T (TT) mutant was an independent risk factor for spontaneous abortion of pregnant women.

Conclusion: MTHFRC677T (TT) is associated with the occurrence of hyperhomocysteinemia, and its high expression often indicates that the risk of spontaneous abortion is greatly increased, which may provide a new research direction for maternal health.

Keywords: Hcy levels; MTHFRC677T; Spontaneous abortion; gene polymorphism; pregnant woman.