The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer

Juan Xu; Xiyi Chen; Yu Sun; Yaqian Shi; Fang Teng; Mingming Lv; Chen Liu; Xuemei Jia

doi:10.3389/fonc.2021.691317

The Regulation Network and Clinical Significance of Circular RNAs in Breast Cancer

Front Oncol. 2021 Jul 9:11:691317. doi: 10.3389/fonc.2021.691317. eCollection 2021.

Authors

Juan Xu¹, Xiyi Chen¹, Yu Sun¹, Yaqian Shi¹, Fang Teng¹, Mingming Lv², Chen Liu³, Xuemei Jia¹

Affiliations

¹ Deparment of Gynecology, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, China.
² Department of Breast, Nanjing Maternity and Child Health Care Hospital, Women's Hospital of Nanjing Medical University, Nanjing, China.
³ Department of Medical Genetics, Nanjing Medical University, Nanjing, China.

Abstract

Breast cancer is one of the most common malignant tumors in women worldwide. Circular RNA (circRNA) is a class of structurally stable non-coding RNA with a covalently closed circular structure. In recent years, with the development of high-throughput RNA sequencing, many circRNAs have been discovered and have proven to be clinically significant in the development and progression of breast cancer. Importantly, several regulators of circRNA biogenesis have been discovered. Here, we systematically summarize recent progress regarding the network of regulation governing the biogenesis, degradation, and distribution of circRNAs, and we comprehensively analyze the functions, mechanisms, and clinical significance of circRNA in breast cancer.

Keywords: biogenesis; biomarker; breast cancer; circRNA; degradation; distribution; oncogenic; tumor suppressive.

Publication types

Systematic Review