Interferon β, an enhancer of the innate immune response against SARS-CoV-2 infection

Microb Pathog. 2021 Sep:158:105105. doi: 10.1016/j.micpath.2021.105105. Epub 2021 Jul 24.


COVID-19 exhibits a global health threat among the elderly and the population with underlying health conditions. During infection, the host's innate immune response acts as a frontline of defense by releasing cytokines such as type I interferon (IFN α and β) thereby initiating antiviral activity. However, this particular interferon response is interrupted by factors such as SARS-CoV-2 non-structural proteins, aging, diabetes, and germ-line errors eventually making the host more susceptible to illness. Therefore, enhancing the host's innate immune response by administering type I IFN could be an effective treatment against COVID-19. Here, we highlight the importance of innate immune response and the role of IFN β monotherapy against COVID-19.

Keywords: Coronavirus disease 2019; Innate immunity; Interferon β monotherapy; Severe acute respiratory syndrome; Type I Interferon.

Publication types

  • Review

MeSH terms

  • Aged
  • COVID-19*
  • Humans
  • Immunity, Innate
  • Interferon Type I*
  • Interferon-beta
  • SARS-CoV-2


  • Interferon Type I
  • Interferon-beta