International Peanut Allergy Prevention, 6 Years After the Learning Early About Peanut Study

J Allergy Clin Immunol Pract. 2022 Jan;10(1):71-77. doi: 10.1016/j.jaip.2021.07.015. Epub 2021 Jul 24.


Six years ago, the Learning Early About Peanut (LEAP) trial findings helped fundamentally shift the paradigm of peanut allergy prevention. Although the results of LEAP are well accepted, policy-makers, caregivers, and clinicians struggle with how best to implement and apply the study's key findings in clinical practice. Differences in guidelines highlight issues related to peanut allergy prevention implementation, including caregiver acceptability, cost, fidelity, feasibility, appropriateness, and adoption. The goals of this rostrum are to review how the LEAP study has informed international peanut allergy prevention policy, as well as to review the strengths and ongoing controversies in peanut allergy prevention implementation.

Keywords: Allergy testing; Cost-effectiveness; Early introduction; Eczema; Implementation; LEAP study; Peanut allergy prevention; Preference-sensitive care; Screening; Shared decision-making.

Publication types

  • Review

MeSH terms

  • Allergens
  • Arachis
  • Humans
  • Infant
  • Peanut Hypersensitivity* / prevention & control


  • Allergens