The tail wags the tubulin

Nandini Mani; Radhika Subramanian

doi:10.1016/j.devcel.2021.06.018

The tail wags the tubulin

Dev Cell. 2021 Jul 26;56(14):2007-2009. doi: 10.1016/j.devcel.2021.06.018.

Authors

Nandini Mani¹, Radhika Subramanian²

Affiliations

¹ Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA.
² Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Genetics, Harvard Medical School, Boston, MA 02115, USA. Electronic address: radhika@molbio.mgh.harvard.edu.

PMID: 34314694
DOI: 10.1016/j.devcel.2021.06.018

Abstract

The C-terminal tail of tubulin influences microtubule assembly and stability. In this issue of Developmental Cell, Chen et al. combine in vitro experiments using recombinant tubulin with molecular dynamics simulations to provide molecular-level insights into the importance of α-tubulin tail and its post-translational modifications in microtubule assembly and stability.

Publication types

Comment

MeSH terms

Microtubules* / metabolism
Molecular Dynamics Simulation
Protein Processing, Post-Translational
Tubulin* / metabolism

Substances

Tubulin