Sequential Use of Aminophylline and Theophylline for Temporizing Neck Cancer-Induced Carotid Sinus Syncope

JACC Case Rep. 2019 Nov 13;1(4):612-615. doi: 10.1016/j.jaccas.2019.09.017. eCollection 2019 Dec.


Carotid sinus syncope due to head and neck cancer is uncommon and the management is challenging. Permanent pacemaker implantation is generally considered but malnutrition with subsequent chemo-radiation increases the risk of device infection. This is a first case report of the sequential use of aminophylline and theophylline for pharmacological temporization. (Level of Difficulty: Advanced.).

Keywords: CR, chemo-radiation; CSS, carotid sinus syncope; PPM, permanent pacemaker; SSS, sick sinus syndrome; aminophylline; carotid sinus syncope; neck cancer; pharmacological temporization; sequential use; theophylline.

Publication types

  • Case Reports