Successful Triplet Pregnancy Post-Allogeneic Stem Cell Transplant in a Patient With Doxorubicin-Induced Cardiomyopathy

Vanthana Bharathi; Mishita Goel; Xavier F Pombar; Sunita Nathan; Tochukwu M Okwuosa

doi:10.1016/j.jaccas.2020.04.020

Successful Triplet Pregnancy Post-Allogeneic Stem Cell Transplant in a Patient With Doxorubicin-Induced Cardiomyopathy

JACC Case Rep. 2020 Jun 17;2(7):987-990. doi: 10.1016/j.jaccas.2020.04.020.

Authors

Vanthana Bharathi¹, Mishita Goel^{1

2}, Xavier F Pombar³, Sunita Nathan⁴, Tochukwu M Okwuosa¹

Affiliations

¹ Department of Internal Medicine, Division of Cardiovascular Diseases, Rush University Medical Center, Chicago, Illinois.
² Department of Internal Medicine, Wayne State University, Detroit, Michigan.
³ Department of Obstetrics & Gynecology, Rush University Medical Center, Chicago, Illinois.
⁴ Department of Internal Medicine, Division of Hematology/Oncology, Section of Bone Marrow Transplant and Cell therapy, Rush University Medical Center, Chicago, Illinois.

Abstract

We report the unique case of a patient who recovered cardiac function despite a history of doxorubicin-induced cardiomyopathy, chest radiation therapy, high dose chemotherapy post-allogeneic stem cell transplant, and triplet pregnancy. Data are sparse on doxorubicin-induced cardiomyopathy in pregnant patients, calling for further studies to help formulate management or surveillance recommendations. (Level of Difficulty: Advanced.).

Keywords: ASCT, allogeneic stem cell transplant; CHF, congestive heart failure; GDMT, guideline-directed medical therapy; LVEF, left ventricular ejection fraction; RIC, reduced intensity conditioning; SCT, stem cell transplant; XRT, radiation therapy; cancer; cardiomyopathy; doxorubicin; stem cell transplant; triplet pregnancy.

Publication types

Case Reports