Massive Myocardial Calcium Deposition: Hardened Heart

JACC Case Rep. 2020 Jun 17;2(7):996-1003. doi: 10.1016/j.jaccas.2020.03.034.


A 25-year-old African-American woman with end-stage renal disease presented with new-onset heart failure. Transthoracic echocardiography indicated a significantly hyperechoic myocardium, and computed tomography noted a circumferential hyperattenuated myocardium. Endomyocardial biopsy revealed focal interstitial and intramyocyte calcium deposition in the heart, confirming a rare diagnosis of massive myocardial calcium deposition. (Level of Difficulty: Beginner.).

Keywords: CT, computed tomographic; EMB, endomyocardial biopsy; ESRD, end-stage renal disease; HF, heart failure; cardiomyopathy; disorders of calcium metabolism; restrictive.

Publication types

  • Case Reports