Acute ST-Segment Elevation Myocardial Infarction as Initial Presentation of Atypical Hemolytic-Uremic Syndrome

Edward Chau; Shiqian Li; Peter Z Xu; Grace X Li; Wesley Ghasem; Ilene C Weitz; Brittney K DeClerck; Eugene C DePasquale; Bassam Yaghmour

doi:10.1016/j.jaccas.2020.12.033

Acute ST-Segment Elevation Myocardial Infarction as Initial Presentation of Atypical Hemolytic-Uremic Syndrome

JACC Case Rep. 2021 Mar 3;3(4):561-565. doi: 10.1016/j.jaccas.2020.12.033. eCollection 2021 Apr.

Authors

Edward Chau¹, Shiqian Li², Peter Z Xu¹, Grace X Li³, Wesley Ghasem¹, Ilene C Weitz³, Brittney K DeClerck⁴, Eugene C DePasquale¹, Bassam Yaghmour²

Affiliations

¹ Department of Cardiovascular Disease, University of Southern California, Los Angeles, California, USA.
² Department of Pulmonary and Critical Care Medicine, University of Southern California, Los Angeles, California, USA.
³ Department of Hematology, University of Southern California, Los Angeles, California, USA.
⁴ Department of Dermatology, University of Southern California, Los Angeles, California, USA.

Abstract

A young woman presented with an acute ST-segment elevation myocardial infarction. Her clinical course was complicated by cardiogenic shock and acute renal failure. Work-up revealed thrombocytopenia and hemolytic anemia. A diagnosis of atypical hemolytic-uremic syndrome was made on the basis of clinical and pathological findings. (Level of Difficulty: Intermediate.).

Keywords: ADAMTS13, ADAM metallopeptidase with thrombospondin type 1 motif 13; COVID-19, coronavirus disease-2019; CRRT, continuous renal replacement therapy; HIT, heparin-induced thrombocytopenia; LV, left ventricular; STEMI, ST-segment elevation myocardial infarction; aHUS, atypical hemolytic uremic syndrome; acute heart failure; autoimmune; cardiovascular disease; myocardial infarction.

Publication types

Case Reports