Eosinophilic Myocarditis in a Patient With Sickle Cell Disease

Hafiz M Imran; Kashif Ather; Ned H Gutman; Michael K Atalay; Athena Poppas

doi:10.1016/j.jaccas.2021.01.006

Eosinophilic Myocarditis in a Patient With Sickle Cell Disease

JACC Case Rep. 2021 Apr 7;3(6):918-921. doi: 10.1016/j.jaccas.2021.01.006. eCollection 2021 Jun.

Authors

Hafiz M Imran^{1

2}, Kashif Ather^{1

2}, Ned H Gutman^{2

3}, Michael K Atalay^{4

2}, Athena Poppas^{1

2}

Affiliations

¹ Division of Cardiovascular Medicine, Rhode Island Hospital, Providence, Rhode Island, USA.
² Warren Alpert School of Medicine, Brown University, Providence, Rhode Island, USA.
³ Division of Cardiovascular Medicine, The Miriam Hospital, Providence, Rhode Island, USA.
⁴ Department of Diagnostic Radiology, Rhode Island Hospital, Providence, Rhode Island, USA.

Abstract

A 23-year-old man with sickle cell disease treated with splenectomy and allogenic stem cell transplantation presented with recurrent chest pain, elevated cardiac enzymes, and unremarkable electrocardiography. His work-up revealed eosinophilia, raising concern for eosinophilic myocarditis. Cardiac magnetic resonance imaging showed patchy late gadolinium enhancement of the left ventricular free wall, suggestive of myocarditis. He was treated with high-dose intravenous steroids followed by oral prednisone, with improvement in his symptoms and eosinophilia and a decrease in cardiac enhancement on follow-up imaging. (Level of Difficulty: Intermediate.).

Keywords: MRI, magnetic resonance imaging; cardiac magnetic resonance; left ventricle; necrosis.

Publication types

Case Reports