Unmasking Hydroxychloroquine Cardiotoxicity in a Patient With Heart Failure and Chronotropic Incompetence

Fatima M Ezzeddine; John R Giudicessi; Joseph J Maleszewski; Peter T Lin; Barry A Borlaug; Jeffrey B Geske

doi:10.1016/j.jaccas.2021.03.003

Unmasking Hydroxychloroquine Cardiotoxicity in a Patient With Heart Failure and Chronotropic Incompetence

JACC Case Rep. 2021 May 26;3(7):997-1001. doi: 10.1016/j.jaccas.2021.03.003. eCollection 2021 Jul 7.

Authors

Fatima M Ezzeddine¹, John R Giudicessi¹, Joseph J Maleszewski², Peter T Lin², Barry A Borlaug¹, Jeffrey B Geske¹

Affiliations

¹ Department of Cardiovascular Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.
² Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA.

Abstract

Chronic use of hydroxychloroquine can result in cardiomyopathy and conduction disturbances. Here, we describe a case of hydroxychloroquine cardiotoxicity in a patient with heart failure with preserved ejection fraction and severe chronotropic incompetence. (Level of Difficulty: Intermediate.).

Keywords: HCQ, hydroxychloroquine; LVH, left ventricular hypertrophy; OSA, obstructive sleep apnea; cardiomyopathy; chronotropic incompetence; exercise; heart failure; hydroxychloroquine.

Publication types

Case Reports